Isotretinoin

links: Retinoic Acid reference: 10-11-2021

Isotretinoin (13-cis retinoic acid) (Accutane) #

I think it lowers IGF-1 to an extreme degree (hopefully that’s temporary) considering accutane rapes the liver. IGF-1 returns to normal after a few months. R

• Impaired locomotion and dopamine signaling in retinoid receptor mutant mice

  • “Isotretinoin and psychopathology: a review” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637283/
    • Reduces D2 and D1 expresion Retinoic acid finds itself in higher concentration in the Striatum and Nucleus Accumbens. Retinoic Acid increases expresion of genes involved in dopamine signal transduction. RA leads to deficits in hippocampal function

• Significantly decreases several 5 alpha reduced androgens after 3 months of use. The expression of the 5-AR1 gene was reduced 2.83 fold along a host of other genes, including 3β-HSD in the skin - the question is whether this occurs elsewhere such as the brain.

  • https://www.reddit.com/r/AccutaneRecovery/comments/o87dc7/post_accutane_and_post_finasteride_syndrome_are/
    • https://www.tandfonline.com/doi/pdf/10.4161/derm.1.3.8258?needAccess=true
  • https://www.pasforum.info/threads/theory-pas-and-pfs-5-alpha-reductase-enzyme-very-plausible-currently-seems-to-be-the-most-likely-cause-of-pas.9/

• By shrinking the sebaceous glands, accutane will end up lowering local DHT, and therefore serum.

• The skin contributes to circulating androgens and estrogens! Skin cells express CYP11A, StAR and MLN64. RPF

• The 25 hydroxy vitamin D and serum calcium levels decreased significantly, whereas 1,25 dihydroxy vitamin D, parathormone, and bone alkaline phosphatase levels increased significantly after 3 months of isotretinoin treatment. Aspartate aminotransferase, total cholesterol, low-density lipoprotein cholesterol, and Triglyceride levels also increased significantly.