PDK1
2022-04-12: reference:
PDK1 (Phosphoinositide-dependent kinase-1) (PDPK1) #
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Has a binding site for substrates, ATP, and the docking site/PIF pocket.
- In signalling cascades you’ll see it directly connected to PI3K, basically.
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Implicated in development/progression of melanomas.
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Its main fnctions here are phosphorylating Protein Kinase B, Protein Kinase C, and S6K.- Notice it is not bound to PIP3 on the right; it does not require activation at the membrane for phosphorylation of many of its substrates (including PKB actually, that’s for another day though).
- So much for the name “Phosphoinositide-dependent kinase”
- ‘H-motif kianse’ isn’t really a distinguished category. I guess it could be a lot of things.
- Notice it is not bound to PIP3 on the right; it does not require activation at the membrane for phosphorylation of many of its substrates (including PKB actually, that’s for another day though).