GSK-3β
2022-04-12: reference:
GSK (Glycogen synthase kinase-3) #
Not exactly for glycogen - acts on >100 different proteins, including Glycogen Synthase, which it inhibits. Exists as GSK-3α and GSK-3β. There is no GSK-1 or -2.
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Deactivated via phosphorylation at Ser9 (or Ser21 in GSK-3α): Inhibited by CAMK II, VEGF, PDGF, Harmine, Lithium, (PKA and AKT R). #
- Indeed, a lot of their effects are by proxy of inhibiting GSK, which prevents β-Catenin stabilization (and the whole complex).
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Inhibits CREB
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Inhibits anterograde transport of BDNF/ANF vesicles.
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I think it’s really the central component of the β-Catenin destruction complex of sorts, where it binds to Axin, APC, and CK1:
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Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?
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