FOXO

2022-06-02: reference:

FOXO (Forkhead Box) #

Transcription factors.

• FOXO3 mediates apoptosis and targets Neuropeptide Y.

• Promotes autophagy/atrophy

• Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing β-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors*

  • Binds to β-Catenin, blocking its function. SIRT1 prevents this binding.

• AKT leads to (irreversible) phosphorylation of FOXO1, preventing nuclear translocation, whereby it is ubiquinated.

  • Blocking this translocation incerases neuron/microglia survival during oxidative stress.

• Acetylation (via HDACi I guess like CREBBP) decreases stability of FOXO1-DNA complex. Increases AKT-mediated phosphorylation (at Ser253) yet inhibits ubiquination. Reversible by SIRT1.