PDRN

2022-08-16: reference:

PDRN (PolyDeoxyRiboNucleotide) (Fish coom) #

Polynuclkeotides derived from stem cell factors.

• Pharmacological Activity and Clinical Use of PDRN
  • So it’s popular in Skincare. You can use it for dermaneedling. Tissue repair, wound healing, anti-inflammatory, etc. Bringing IL-10 up, bringing down TNF-α, IL-6, BAX, etc.
  • A2A activator, and offers nucleosides and nucleotides for the so called “salvage pathway.” (of DNA synthesis or something)
    • A2A activation -> VEGF, Angiopoietin, FGF, EGF, IGF. And PKA-> NF-κB, CREB, HIF-1α.

• Activation of A2A Receptor by PDRN Reduces Neuronal Damage and Stimulates WNT/β-CATENIN Driven Neurogenesis in Spinal Cord Injury #