Detoxification
10-30-2021 links: Liver Drug Metabolism reference:
Detoxification #
-
Adequate B1, B2, Dietary Protein, and Vitamin C helps.
-
Phase I (Modifiation: oxidation, reduction, hydrolysis, (de)cyclization, etc.)
- CYP1A1, CYP1A2 (both 2-hydroxylation), and CYP1B1 (4-hydroxylation). However, excessive activity of these without adequate phase II is not good, since these metabolites are carcinogenic, via production of free radicals, etc.
- These metabolites are more hydrophillic/water soluble.
- Cruciferous vegetables and seafood boost this. Inhibitors are black raspberry, blueberry, Quercetin, grapefuirt, kale, garlic, etc.
-
Phase II (Conjugation)
- Phase II conjugates an endogenous hydrophilic substance to its reactive site so that it’s even more water soluble and ready for detoxification. Conjugation here is mainly processed via Glucuronidation, via any type of UGT enzyme.
- UGT enhancers include cruciferous vegetables, citrus, dandelion, curcumin, et al.
- D-glucaric acid for the UGT enzymes. (Phase II)
- Citrus, curcumin, amongst other things boost UGT enzymes. Oranges, apples, carrots, grapefruit, grape, peaches, plums, lemons, green pepper, tomato, and potatoes can supply it.
- The enzyme β-Glucuronidase reverses the UGT conjugation. Inflammed tissue contains high amounts of it; it counters the detoxification process.
- Lower with saturated fat, and proanthocyanidin-rich foods, like strawberries, cocoa, calcium, magnesium, vitamin C, et al.