B2

links: Vitamins & Minerals reference:

• https://chrismasterjohnphd.substack.com/p/058-why-you-should-manage-your-riboflavin 4-12-2021

B2 (Riboflavin) #

• Calcium can decrease absorption
• Antagonizes TLR4, the Endotoxin receptor
• Good for joints?
• Cofactor for converting Vitamin D into its active form. RPF
• Oily hair is associated with low levels
• I think it can inhibit DHT.
• Gigadose to reset Gut; it helps metabolize things like TMA
  • Vitamin B2 (riboflavin) Is Endotoxin (LPS / TLR4) Antagonist
  • Riboflavin As The Next Generation Prebiotic Supplement
  • Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections
  • Vitamin B2 (riboflavin) Positively Modulates The Microbiome
• Converts Pyridoxine to its active form in the liver - or something like that

Cofactor #

• MAO-A

Supplementation #

All I know is I think 10mg is quite high.

• Very light sensitive - so much so that milk left on your doorstep might have its B2 degraded! R
  • This has implications for Red Light and sunlight. Peat said >20 mg risks: it can reach the level in your skin and your eyes where it sensitizes you to the sunlight. Even blue light will react with riboflavin in your eyes and skin, causing free radical change. Some people on Longecity noticed that taking high dose of B2 before sleep increased their thinking the next day. I’m not sure it’s very physiological use of it, but it didn’t hurt me badly when I tried.
• According to Haidut, riboflavin-5-phosphate is comparable to P5P in that it’s about 10x as potent. I really haven’t seen proof for this, though.
• 10mg/day or so is safe.