@Dehydroepiandrosterone sulfate and estrone sulfate reduce GABA-recurrent inhibition in the hippocampus via muscarinic acetylcholine receptors (Steffensten et al. 2006)

2021-11-19 links: DHEA Estrone GABA Hippocampus

(Steffensten et al., 2006) Dehydroepiandrosterone sulfate and estrone sulfate reduce GABA-recurrent inhibition in the hippocampus via muscarinic acetylcholine receptors #

• Estrogen increases Basal Forebrain Choline Acetyltransferase activity (Luine, 1985), high-affinity Choline uptake (Gibbs, 2000), Acetylcholine release (Gibbs et al., 1997), and some estrogen effects on hippocampal excitatory synaptic function are blocked by M2 AChR antagonists. However, as mentioned earlier, a second possibility is that estrogen acts directly on cholinergic septohippocampal projection neurons to increase ACh release (Gibbs et al., 1997), and thereby influences a subset of hippocampal GABAergic synapses that is sensitive to ACh modulation.
• DHEA synchronizes hippocampal unit activity to theta rhythm.
• M2 AChR agonist, DHEAS, and ES markedly reduced Paired-pulse inhibition in the dentate gyrus and CA1 (which was then blocked by an M2 antagonist).
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