Agomelatine

2022-09-03: Drugs reference:

Agomelatine #

• Atypical antidepressant. Melatonin Receptor 1/2 agonist. 5-HT2C and 5-HT2B antagonist. It can give visuals.
• Possibly liver toxic. So the risk is reduced with sublingual.
• Decreases Tryptophan Hydroxylase expression and improves kynurenine aminotransferase
• The Impact of Chronic Mild Stress and Agomelatine Treatment on the Expression Level and Methylation Status of Genes Involved in Tryptophan Catabolic Pathway in PBMCs and Brain Structures
  • Downregulates Kmo (Kynurenine 3-monooxygenase)
• Scaffold hopping of agomelatine leads to enhanced antidepressant effects by modulation of gut microbiota and host immune responses
• It’s smart to take it with melatooonin, since CYP1A inhibition cancels its toxicity

Dosing #

• ~15mg buccal/subL (25x as effective compared to oral; also mitigates liver damage to negligible levels apparently).
• JC Denton + Lov on qwerkyscience says it makes dreams more romantic, positive, and epic.