Melatonin Receptor

2022-09-12:

Melatonin Receptor #

• MTNR1A (MT1)
  • Coupled to both Gq and Gsi.
• MTNR1B (MT2). MT3 in birds and amphibians.
  • Gi-coupled. Possibly Gq as well?
• There are heteromers of: MT1-MT2, MT2-5-HT2C.
• Activation of melatonin receptor 1 by CRISPR-Cas9 activator ameliorates cognitive deficits in an Alzheimer’s disease mouse model
  • Expression decreases with aging and AD progression
• Expressed on Pancreas islets, and inhibit Insulin production.
  • This seems like a good way for keeping blood glucose at a healthy high level at night without having to secrete Glucocorticoids.