Acrolein

2022-02-08 links: reference:

Acrolein #

‘The simplest unsaturated Aldehyde… The smell of burnt fat when cooking is caused by Glycerol breaking down into acrolein’

• Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures
• (Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer’s disease)
  • Mitochondria membranes contain a significant amount of Arachidonic Acid and Linoleic Acids, precursors of lipid peroxidation products, 4-hydroxynonenal (HNE) and 2-propen-1-al (Acrolein), that are extremely reactive. Both alkenals are increased in Alzheimer’s brain.
  • Acrolein decreased Pyruvate Dehydrogenase and ketoglutarate dehydrogenase activities significantly in a dose-dependent manner.
  • Acrolein was found to bind Lipoic Acid, a component in both the PDH and KGDH complexes, most likely explaining the loss of enzyme activity.
  • Acrolein also interacted with NAD+ in such a way as to decrease the production of NADH.