Proopiomelanocortin

2022-04-07: reference:

Proopiomelanocortin (POMC) #

Secreted by the Pituitary Gland as well as the Arcuate Nucleus.

• It’s 241 amino acids. After POMC’s synthesis, it is cleaved, whereby each of the following is packaged into vesicles:

  • N-Terminal Peptide of Proopiomelanocortin (NPP/Pro-γ-MSH)
    • γ melanotropin
  • Adrenocortocotropic Hormone (corticotropin)
    • MSH (AKA α-melanotropin)
    • CLIP (corticotropin-like intermediate peptide). Not cleaved
  • β-lipotropin
    • γ-lipotropin
      • β-melanotropin (not naturally produced in humans)
    • β-Endorphin
      • Met-Enkephalin The question is if this happens in one fell swoop or something else…

• https://en.wikipedia.org/wiki/Proopiomelanocortin#Regulation_by_the_photoperiod Seems it has connections with T3 - I think it’s antagonistic in this pathway