Tau

2022-03-04: reference:

NFTs (NFTs!!!! no way bro!!) are when tau proteins become hyperphosphorylated.
Their pathologies are somewhat unknown (maybe not even causal), but are major biomarkers for neurodegenerative disorders e.g. Alzheimer’s/Parkinson’s. They disrupt the cytoskeleton.
- GSK-3β is implicated in hyperphosphorylation; it has been referred to as Tau-protein kinase.
- CDK5 seems to also be prevalent
- PP2A inhibition induces hyperphosphorylation. R
Produced by the gene MAPT (Microtubule-associated protein tau). They assist their assembly/stabilization an are found only in axons.
Signals Kinesin/Dynein where to termiante/jump off. Acts as a guide of sorts
Soluble tau (as opposed to… insoluble?) is the more toxic species

yana-notes