yana-notes

Sunifiram

2022-03-03: Nootropics reference:

Sunifiram #

Related to unifram (and despite “uni” in their names - they did not bind to glu/gaba,5ht/da/adrenergi/histamine/ach/opioid/ampa.)

  • Stimulates CAMK II and Protein Kinase Cα by means of (agonizing, I assume) the glycine site of NMDAR. Along with racetams, it antagonizes barbituate-induced inhibition of glucose transport.
  • [Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers.]
    • Increase Acetylcholine release in rat cerebral cortex.
    • Unifiram increases fEPSP amplitude in rat hippocampal slices.

Unifiram #