Sialin

2022-09-04: reference:

Sialin #

• Identification of a vesicular aspartate transporter
  • When present in synaptic vesicle and SLMVs, sialin is responsible for vesicular storage and subsequent exocytosis of Aspartic Acid and Glutamate. When present in lysosomes, it acts as an H+-coupled Sialic Acid exporter. Because all criteria for aspartate as a neurotransmitter are now satisfied, sialin should be a missing link in aspartergic neurotransmission and the sixth member of the vesicular neurotransmitter transporter family, which comprises VMAT, vesicular acetylcholine transporter, vesicular inhibitory amino acid transporter, VGLUT, and VNUT.
  • Should be renamed VEAT
  • The present work predicts that glutamatergic neurotransmission is always accompanied by an aspartergic one. Sialin can be used as a marker for aspartergic neurons to explore the occurrence of aspartergic and associated glutamatergic neurotransmission in the central nervous system