VMAT

2022-08-11: reference:

VMAT #

• Bipolar patients have overexpressed vesicular transporters as the brain desperately tries to compensate but this doesn’t produce a favorable state as the vesicular transporters are barely functional in the normal comformation due to the deficiency of cellular energy and when the brain senses neurotransmitter release is needed, the bipolar brain has no choice but turn to an amphetamine-like state - vesicular and presynaptic terminal transporters change comformation and leak neurotransmitters irrespective of cellular energy. This aberrant function is incredibly unhealthy and can lead to Parkinson’s. Schizophrenia implicates the same problem - overexpressed vesicular transporter expression, mitochondrial dysfunction and reversed comformation of vesicular and presynaptic terminal transporters, tho’ the schizophrenic brain has this state chronically as opposed to the bipolar brain that displays this intermittently.The problem with depression is simply a deficiency of the vesicular transporters…
• There is no antioxidant that will absolutely save your cells from oxidation. With simple chemistry there is always off target effects and metabolites. Glutathione for example can be neuroprotective but some of the catecholamine-glutathione-derivative metabolites DESTROY the brain by causing apoptosis. The only thing that will absolutely protect from oxidation is segregation of molecules that are prone to oxidation into compartments devoid of oxygen. Which is exactly what vesicles are. They’re insanely energy-intensive compared to any other structure in the body, but for a good reason, I believe much of the energy spent by the brain is spent on loading vesicles.