Serine-Threonine Protein Kinase

2022-02-19 links: Protein Kinase reference: http://www.kinasenet.ca/

Serine/threonine Kinase #

Phosphorylates the hydroxyl of Serine OR Threonine residues off a peptide. Kinases can phosphorylate residues that are embedded within ‘phosphorylation consensus sequences’ of amino acids.

• Many have a regulatory (R) and catalytic (C) domain (I believe all R/C domains are on the C/N terminus respectively, but this is not the case with all kinases: the opposite is true for RTKs.), whereby something binds to R for activation, and the C group is where phosphorylation takes place.

• =125 of the 500+ human protein kinases, including:

  • Protein Kinases
  • Protein Phosphatase
  • MAPKs
    • ERK1/2
  • CAMK
    • CAMKK
  • GSK-3β They play a role in regulation of proliferation, differentation, apoptosis, and embryonic development onto a substrate.s