yana-notes

MAPK

2022-04-12: reference:

MAPK (mitogen-activated protein kinase.) #

  • Phosphorylated by MAPKK/MAP2K/MEK, itself phosphorylated by MAP3K and so on: (It stops at MAP4K: mitogen-activated protein kinase kinase kinase kinase. What were they thinking man?)

    • Cascades: 500
      • ERK
        • MAPK3 aka ERK1
        • MAPK1 AKA ERK2
        • Activated by Ca2+ influx… at least part of it.
      • JNK (1-3)
      • p38 (α, β, γ, δ)
  • So this is a clusterfuck:

    • MAPKAPK2 is MAPK-activating protein kinase, but there is also
    • MAP2K which is MAPK kinase, and MAP3K which is MAP2K kinase. Thank god it stops at MAP4K.