Rho

2022-05-25: reference:

Rho #

• Divded into Rho proper, Rac, and Cdc42.

  • Cdc42: ->(PAK -> LIMK -x Cofilin->Actin turnover) ->(WASP->Arp2/3->Actin polymerization)
    • Cdc42, Rac1, RhoA, Ras are all activated by CAMK II: Plasticity of dendritic spines: Molecular function and dysfunction in neurodevelopmental disorders
      • Some sources show LIMK (activated by PAK and ROCK) as a cofilin activator fore som reason. Maybe just due to semiotic incompetency.

• [Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities] really good paper on Axon Guidance

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  • They are indeed membrane-bound. Maybe all G-proteins.

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• I’ll just put this into text for the sake of my sanity or something… when I find out where even to begin. Laminin and ROCK inhibition is the name of the game… look ahead…

• Like yeah this looks significant but holy moly there’s so much. I don’t know how downstream this even is.