Axon Guidance

2022-03-11: Neurogenesis reference:

Axon Guidance #

The process begins when growth fators bind to receptor tyrosine kinases to cause polymerization of actin filaments.

• Axon guidance is a process of neuronal development facilitated by the growth cone.
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  • In the immediate extracellular environment, there are various repellent and attractant cues, which can be anything from BDNF to ?
• The filopodia (the F-actin therein known as microspikes) and adhesion receptors (cadherin, found on both the growth cone and ECM, binding to itself.) bind to
• Integrins also facilitate adhesion to the ECM, binding to Collagen, Fibronectin, Laminin, and vitronectin.
• The lamellipodia are composed of actin meshwork as opposed to F-actin.
• Growth cones are as represented above when nonpolarized, but then the microspike projections become attracted and all go in a certain direction.
• In the Neuromuscular Junction for instance, contact between growth cone and developing muscle fiber initiate pre- and postsynaptic differentiation. The growth cone becomes a proper terminal and the postsynaptic site activates genes encoding ACh receptor subunits.
• Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration (this is insane stuff on Actin, ROCK, etc.)
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