PTEN

2022-04-13: reference:

PTEN (Phoshatase and tensin homolog) (PIP3 phosphatase) #

• One often sees it characterized as a tumor suppressor, since PIP2 apparently prevents cells from growing/dividing too rapidly. And I guess it’s technically an mTOR inhibitor.

• Hydrolyzes PIP3 into PIP2 + phosphate, basically reversing the actions of PI3K.

  • So far I’ve only seen it regarded as an inhibitor of PI3K’s actions, but I wonder if PTEN plays a function akin to ATP Hydrolysis.
    • Yes, I suppose it’s step 1 since I forgot phospholipase C cleaves it into IP3 + DAG . IP4 is a thing but it’s probably not at all common. A recognized risk gene in Autism; mutations (of excessive activity) contributes to the pathophysiology and synergizes with other mutations seen in ASD. R R

• Histone acetyltransferase PCAF represses its activity, while HDAC1 and SIRT1 stimulate its activity via deacetylation.