PRL-8-53

inks: Nootropics reference: 10-16-2021

PRL-8-147 is supposedly a more powerful version of PRL-8-53. Hasn’t been synthesized. PRL = Pacific Research Laboratories. Created in 1974. Hypermnesic, spasmolytic. Only two studies done on it, in ‘74 and ‘78. Derived from benzoic acid and Phenylmethylamine.
Increased learning of words by 87.5-105% in poor performers, and 7.9-14% in high performers - but that’s just due to a ceiling effect. Was #1 by a decent margin in the /r/nootropics survey for memory.
Displays Cholinergic properties (probably ACh uptake/synthesis). Potentiates Dopamine and partially inhibits Serotonin signalling, and maybe synthesis.
- Indeed, Blank always says it doesn’t really work without choline. Especially when stacked with TAK, for whatever reason.
- It may inhibit the reuptake of dopamine, which depending on the mechanism such as DAT, may not be good long term. Also may be a direct agonist, though no stimulant-like symptoms have been shown even up to 200mg/kg.
- Possibly a M2 AChR agonist.
- Sirsad suspects it’s a DAAO inhibitor
20mg/kg does not potentiate dextroamphetamine - good to know I guess.
Possibly a HDAC inhibitor. Very contentious.

~3-5hr half life. Some people feel the effects for days though; I think it has to be cycled a bit.
5, 10, 20mg or so, sublingually. Has a fun numbing effect. Too much will make you feel groggy. The LD50 is like 700mg/kg. There are some noted side effects at high doses but don’t see anything at things like <1mg/kg.
- Personally, anything over 5mg makes me tired.
- Potential did 5mg/day 5x/week for a year - intranasal.
  - So, I’ll see first if 12.5mg/, or maybe 25mg/mL.
    - Forgot which one my current bottle is (I think I did 10mL + 250mg tbh), but whatever it is, it hurts like a fucking bitch. Doing like .5mg a spray or something isn’t bad.
Might not want to take it too often; like once a week?

yana-notes