α2A
2023-03-18:
α2A α2 Adrenergic Receptor #
- (Gi)
- Majority is postsynaptic.
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Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
- Inhibits neurotransmitter release at high stimulation frequencies, while α2C is for lower levels of nerve activity.
- Anxiolytic; reduces Blood Pressure
- There exist α2A-serotonin heteroreceptors. Clonidine inhibits Dorsal Raphe Nucleus firing.
- Psychostimulants Modafinil, Atomoxetine and Guanfacine Impair Bone Cell Differentiation and MSC Migration it’s over.
- Alpha2-adrenoceptor mediated co-release of dopamine and noradrenaline from noradrenergic neurons in the cerebral cortex
- Stimulation of the locus coeruleus elicits noradrenaline and dopamine release in the medial prefrontal and parietal cortex
- Activation of a novel α2AAR-spinophilin-cofilin axis determines the effect of α2 adrenergic drugs on fear memory reconsolidation Clonidine, but not guanfacine, promotes actin and Cofilin interaction to induce spinophilin to induce cofilin activation at the synapse.
- Presynaptic gets desensitized when agonized with Guanfacine, but postsynaptic does not. Presynaptic is responsible for sedation.