NLRP3
2022-12-07:
NLRP3
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- When inactive, it complexes with SGT1 and Hsp90, which dissociates whereby ASC-Pro-Caspase 1 is recruited to the complex.
- Downregulator of AMPAR.
- Deletion ameliorates ameliorates mouse models of diseases like gout, type 2 Diabetes, Multiple Sclerosis, Alzheimer’s, and atherosclerosis.
- Ginseng downregulates it.