M-CSF

2022-07-03: reference:

Macrophage colony-stimulating factor (CSF1/M-CSF) #

• A Cytokine which mediates hematopoietic differentiation into Macrophages.
• Binds to CSF1R, which are increased in number in microglia in neurodegenerative disease like Alzheimer’s and brain injury.

• Colony-stimulating factors are glycoproteins that each bind to a corresponding receptor. Upon addition to cultured hematopoietic Stem Cells, they differentiate.
• Soluble
• Also CSF2 aka GM-CSF (granuocyte macrophage) and CSF3 aka G-CSF (granulocyte)