Stem Cell

2022-03-31: reference:

Stem Cell #

• Urine-Derived Stem Cells for Epithelial Tissues Reconstruction and Wound Healing
• What’s interesting about them is that the hayflick limit does not apply
• The Yamanaka factors are cMyc, Oct3/Oct4, Sox2, and Klf4. They turn somatic cells into induced pluripotent stem cells.
  • Yamanaka’s research relied on/was inspired by earlier work MyoD which reprograms muscle lineages.
  • The most well-known natural pluripotent stem cells are embryonic stem cells.
• Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells
  • Blank: this research is a total frickin mess so don’t expect a proper explanation for a long time but this endothelial niche is one of the reasons why I think skq1 is actually neurogenic, apart from my personal experience with it Inflammation itself is probably anti-neurogenic so just mitigating that should lead to more neurogenesis skq1 affects a ton of genes involved with endothelial cells and tight junctions… well the effects on endothelial genes might be a result from lower inflammation.