JAK
2022-07-03: reference:
JAK #
- Consists of JAK1-3 and Tyk2.
- Its ligands are typically Cytokines.
- JAK-STAT is involved in immunity, proliferation, apoptosis, oncogenesis (regulating/inhibiting), etc.
- Non-receptor tyrosine kinase, however, they still localize(/attach I assume) to the C-terminus of… receptors. But they are not a receptor themselves and are found in the cytosol.
- pSTAT then activates PI3K, Ras pathway, and the proteasome @ ISRE and GAS.
- Increases p21 expression.
- JAK2 has no Src domains.