Kanna

2022-04-30: reference: 2022-02-04

Kanna (Sceletium tortuosum) #

Very rare. Have to go on reddit to find actual growers like from South Africa; the other stuff is just a different plant with similar alkaloids. Contains a few non-psychedelic alkaloids.

• Inhibits Acetylcholinesterase.
  • VP doesn’t consider it much of an SSRI, I guess due to the dose required.
• Upregulates VMAT2, making it a monoamine-releasing agent (MRA) - this also includes histamine and GABA.
  • VP says the VMAT2 upregulation might only be on serotonergic neurons.,
• Upregulates TAAR1; the only thing that does, according to Uxkull.
• Possible cannabinoid agonist.
• Increases C-Reactive Protein?
• Contains the alkaloids:
  • (Δ7-)mesembrenone: SSRI and PDE4 inhibitor.
  • Mesembrine: SSRI, PDE4 inhibitor, MRA, VMAT2 upregulator.
    • ~500μg pure is probably the highest safe does according to VP.
    • MAO-Ai is basically negligible.
  • Mesembrenol
  • Tortuosamine
• [Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids]
  • 
  • 4.6 IC50 on SERT. 236 IC50 on δ-Opioid Receptor—so is that negligible or what?
• High-mesembrine Sceletium extract (Trimesemine™) is a monoamine releasing agent, rather than only a selective serotonin reuptake inhibitor - in vitro
  • Only mild AChEi.
  • 1 mg/ml of pure mesembrine achieved only a E30% AChE in hibition, while the complete alkaloid extract from Sceletium tortuosum inhibited AChE in a dose-dependent manner, with the highest concentration assessed (1 mg/ml) resulting in 87% inhibition, which suggests that the non-mesembrine portion of Sceletium may be responsible for the plant’s inhibitory effects on AChE activity. Somewhat surprisingly, a whole extract with low mesembrine content was reported to only inhibit acetylcholinester-ase activity by 7% (Harvey et al., 2011).
• Cannabinoid CB1 receptor binding and acetylcholinesteraseinhibitory activity of Sceletium tortuosum L.
• Modulation of glucocorticoid, mineralocorticoid and androgen production in H295 cells by Trimesemine™, a mesembrine-rich Sceletium extract

Dose/Source #

• https://tristill.com/trimesemine/ a properietary blend of mesembytheuym alkaloids. Liftmode is legit.
• Take buccaly/sublingually.
• Headaches when taken in high doses andor when insufflated.
• I hear it can be anxiogenic during the comeup before anxiolytic.

<10mg/day (extract). Doesn’t scale that much with dose.

Insufflation lasts 30-90 minutes, peaking around 5-10, with a 0-5 minute onset. Oral: 4-6 hours; 30-60 minute onset.

• Priming? Taking a few doses before you actually start to feel it.
• MX12 extract from Ultrakanna: https://www.ultrakanna.com/product/mx-12-powder-extract-1g/