Interferon-γ
2021-12-14 links: reference:
Interferon Gamma #
- Important activator of macrophages. Cytokine produced by natural killer cells.
- Effects: STAT1/2, NF-κB.
- In experiments, administration decreased serum Tryptophan by 50% with no significant effect on other amino acids.
- Induces liver tryptophan dioxygenase. Possibly related is its upregulation of indolamine dioxygenase everywhere else. This increases Quinolinic Acid (QA).
- Interferon-gamma is a potent inducer of catagen-like changes in cultured human anagen hair follicles