@Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication (Lauritzen et al. 2021)

2021-12-03 links: NAD+ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7963035/figure/F3/?report=objectonly cool pix

@Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication (Lauritzen et al., 2021) #

• PARP enzymes initiate mtDNA repair mechanisms, using NAD+ as an energy source. High levels of mice cardiomyocyte mtDNA damage cause a reduction in NAD+ levels due to extreme DNA repair activity, impairing activation of SIRT3.
• Myocardial mtDNA damage combined with high doses of Nicotinamide Riboside causes inhibition of Sirtuin activity due to accumulation of Niacinamide, in addition to irregular cadiac mitochondrial morphology.
  • “We show that Nicotinamide Riboside, particularly at high doses, had the opposite effects in cardiac tissue potentially secondary to enhanced NAM evels that would inhibit SIRT3 activity.”

I gotta check out the discussion.