Histidine

links: reference: 9-8-2021

Histidine #

• Higher blood levels actually inhibit Mast Cell release of histamine.
• Tadaho Nakamura has interesting articles on Histamine and cognition.
  • [Oral histidine intake improves working memory through the activation of histaminergic nervous system in mice.]
• Binds to Fe3+ and hydroxyl radicals.
• Role of dietary histidine in the prevention of obesity and metabolic syndrome
  • Obese middle-aged chinese women received 2g 2x/day for 12 weeks. Average fat loss in the histidine group was 2.71 kg and TNF-α, IL-6 decreased.
  • Histamine decreases Gluconeogenesis enzymes, most notably Glucose 6-Phosphatase.
• Benefits and Adverse Effects of Histidine Supplementation

Supplementation #

• Per 500mg histidine, something like 15-20mg zinc, which it chelates.
• The redsun stack is 2-4g, along with <25mg P5P and <15mg zinc, with protein/meal. Indeed histidine depletes Zinc.
• When I take zinc my immune system goes nuts - severe pain, hives, diarrhea, hayfever, brain swelling, etc. But if I take it along with histidine I’m okay, so we were sure that I didn’t have enough histidine to help with metallothionein formation and the free zinc caused the reactions. On the other hand, not getting enough zinc while on histidine can cause constipation, stuffy nose and a greater susceptibility to bacterial infections and viruses, so it is very important to get some zinc every day along with histidine.