Gluconeogenesis

2022-05-04: reference:

Gluconeogenesis #

• The Cori cycle is a significant contributor of substrate, and increases during fasting where it can eventually reache >90%.
  • The Cori cycle is glucose’s fate being Lactate Dehydrogenase in the muscle, but reversing when Lactate reaches the liver, back to pyruvate and to glucose, to be used again in muscle/other tissue.
    • This is not free energy, since glycolysis produces 2 ATP but gluconeogenesis from pyruvate consumes 6 ATP.
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  • PEPCK expression in Adipose is increased by cortisol/glucagon. I think this leads to less recycling of FFAs, leading to higher FFA blood levels. And PEPCK stimulates triglyceride synthesis