HNE

2022-02-08 links: reference:

4-Hydroxynonenal (HNE/4-HNE) #

• A α,β-unsaturated hydroxyalkenal (0αβUA) (lol.)

• Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer’s disease

  • Previously we showed that HNE-modified proteins, markers of lipid peroxidation, are elevated in MCI (mild cognitive impairment) hippocampus and inferior parietal lobule
  • 11 HNE-modified proteins that had significantly elevated HNE levels in MCI patients compared with controls that span both brain regions:
    • Neuropolypeptide h3, carbonyl reductase (NADPH), alpha-enolase, Lactate Dehydrogenase B, phosphoglycerate kinase, Hsp70, ATP synthase alpha chain, Pyruvate Kinase, Actin, elongation factor Tu, and translation initiation factor alpha.
      • The enzyme activities of Lactate Dehydrogenase, ATP Synthase, and Pyruvate Kinase were decreased in MCI subjects, suggesting a direct correlation between oxidative damage and impaired enzyme activity
    • We suggest that impairment of target proteins through the production of HNE adducts leads to protein dysfunction and eventually neuronal death, thus contributing to the biological events that may lead MCI patients to progress to Alzheimer’s

Metabolism #

‘A small group of enzymes are specifically suited to detoxification/removal of 4-HNE from cells’ including Glutathione S-Transferase and others