Actin

2022-02-08 links: reference:

Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
- Human risk alleles for these disorders (ASD, schizophrenia, intellectual disability) in genes, such as SHANK3, GIT1, DISC1, SRGAP3, OPHN1, LIMK1, NRG1, CYFIP1, SYNGAP1, KALRN, NCKAP1, and CNKSR2.
- Prefrontal 3 expression decreased in indivbiduals with schizophrenia.
Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo
- This increase in F-actin involves inhibition of actin’s depolymerization.
- G-actin = free subunits or something bound to ATP, while F-actin is the polymer.

yana-notes