HA-FGL

links: Nootropics Neuropeptide reference:

• https://www.reddit.com/r/DrugNerds/comments/hydv2u/hafgl/
• https://sci-hub.st/https://www.sciencedirect.com/science/article/abs/pii/S0168365919303426 11-14-2021

HA-FGL #

• Agonizes FGFR1 and 2, and a concomitant increase in NCAM. It’s derived from NCAM.
  • FGFR -> PLC -> PKC -> mediates AMPAR membrane insertion.
  • PLC -> very marked influx of Ca2+ -> Apoptosis such that standard use every 2 days for a period of 2 weeks utterly destroyed half of the brain volume of mice despite their memory improving. WHAT THE FUCK?
  • PLC -> Ca2+ -> CAMK II -> GSK-3β inhibition. Promotes D2 activity, which stimulates CNTF.
    • I think the apoptosis might be due to this excessive GSK-3β inhibition.
• Competes with ATP at the receptor? Wild
• Stimulates brain Angiogenesis as long as it’s active.
• Ampakine/ampakine-like activity.

Supplementation #

One guy’s manic ramblings on advanced nootropics said it helped with meditation.

• Intranasal/sublingual in DMSO or IV.