Galantamine

links: Drugs reference: 10-28-2021

Galantamine #

Long-acting (competitive) inhibitor of Acetylcholinesterase in the whole body.

• Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptors
• Potent PPAR-γ agonist?? May increase mortality?
• Long half-life, I think.
• New prodrug ‘memogain’ is coming out that’s selective for the brain, and is then metabolized therein into galantamine. This is to avoid systemic/GI sicde effects like nausea and diarrhea.

Supplementation #

People take 4-8mg after 4.5-6 hours of sleep, wait 30 mins, then sleep again.

• Relentless improvement brand?
• I don’t believe it has tolerance, but it and other rapidly irreversible AChEis upregulate AChE with long-term use: Acetylcholinesterase and its inhibition in Alzheimer disease