Depression

links: reference:

• Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression (Allen et al., 2018) 8-29-2021

Depression #

• 33% lower 5-HT2A binding in BA 41/42 in individuals who had an MDE than in controls. Neither 5-HT1A nor SERT binding in BA 41/42 differed between individuals who had an MDE and controls. We also found 14% higher 5-HT1A receptor binding and 21% lower SERT binding in BA 9 of individuals who had an MDE. R
• The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder
  • Recent studies demonstrate that rapid antidepressant response to Ketamine is mediated by activation of the mammalian target of rapamycin (mTOR) signaling pathway, leading to increased synaptic proteins in the prefrontal cortex (PFC) of rats.
    • Defecits in the PFC in MDD of NR2A, NR2B, PSD-95, mGluR5
    • Specifically. significant reduction in mTOR, p70S6K, eIF4B and p-eIF4B protein expression in MDD subjects relative to controls. No group differences were observed in eIF4E, p-eIF4E or actin levels..