yana-notes

DXM

2022-05-28: Drugs reference:

DXM 150 #

SSRI, σ1 agonist in high doses, and its dextrorphan metabolite is an uncompetitive NMDAR antagonist, negative allosteric modulator of some nAChRs. Slightly dopaminergic too I think?

Dose #

  • 2.75-7.5mg/kg for second plateau. 7.5-15mg/kg for third plateau. 15+ is fourth pleateau and very fucked. >25mg/kg can be deadly.