Citric Acid Cycle

links: reference:

• https://www.youtube.com/watch?v=FmEm0CgHGdA
• https://raypeatforum.com/community/threads/vos-uncoupling-thread.5037/ 4-16-2021

Mitochondrial Respiration #

Several components/reactions of the citric acid cycle were established in the 1930s by Albert Szent-Györgyi.

Cycle/Citric Acid Cycle #

• Considering proteins and so on are phosphorylated purely for inducing confortmations, it’s not like this is the be-all end-all fate for ATP… unless?
• Two cycles of 3 NADH, 1 [FADH2], 1 ATP, 2 CO2 per cycle.
  • NADH inhibits every (regulatory) enzyme in it.
  • ATP allosterically inhibits Pyruvate Dehydrogenase, citrate synthase, and isocitrate dehydrogenase. Probably others

1. Glucose is first turned into Pyruvate via Glycolysis.
2. Pyruvate enters the mitochondrial matrix, decarboxylates and oxidizes (via NAD+, turning it into NADh) to combine wihh CoA to form Acetyl-CoA. Unless in the lack of oxygen, in which case the pyruvate will ferment into lactate.
3. Aldol condensation: [Acetyl CoA] is converted via citrate synthase into citrate.