CYP2D6
2022-07-16: reference:
CYP2D6 #
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Quiite important for drug metabolism, including:
- most SSRIs, stimulants, Tropisetron, psychedelics, etc.
- Conversion of p-Tyramine to dopamine.
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Inhibited by Quinine, Fluoxetine, Bupropion (strong in vitro, weak in vivo. As well as its metabolites), Modafinil and CBD.
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“Weakly” inhibited by Fluvoxamine, Methylphenidate, Mirtazapine, Sertraline, … of course there are many others but that’s just what I know. Induced by Nicotine.
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CYP2D6 is not present in rats, which express a homologous but functionally distinct cytochrome P450 2D1