Aripiprazole

2022-08-23: Drugs reference:

Aripiprazole #

Atypical antipsychotic.

• 5-HT1A (Ki 1.7-5.6) ( IA 68% - partial agonist)
• 5-HT2A (Ki 3.4-35) (IA 12.7 - antagonist)
• 5-HT2B (Ki 0.11-0.36 - inverse agonist)
• 5-HT2C (Ki 15–180) (IA 82% - partial agonist)
• 5-HT7 (Ki 9.6-39) (Antagonist)
• D2 (Ki 3.3) (IA ~25% - partial agonist)
  • D2L (Ki 0.7-1.2) (Partial agonist)
  • D2S (Ki 1.2) (Partial agonist)
  • Apparently has antagonist activity on postsynaptic D2, but this partial agonism at presynaptic D2.
• D3 (Ki 0.8-9.7) (Partial agonist)
• Hypersexuality and new sexual orientation following aripiprazole use