ASP2905

links: Nootropics reference: 11-10-2021

ASP2905 (EM902) #

AKA… N-(4-fluorophenyl)-N’-phenyl-N"-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine. Lol.

• Inhibitor of KCNH3

• A: 10mg/kg ASP2905; B: amphetamine 3mg/kg; C: methylphenidate 3mg/kg.

• 

• ASP2905, a specific inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3 gene, is psychoactive in mice

  • Inhibited meth-induced hyperlocomotion, but did not affect spontaneous locomotion.
  • Treats certain symptoms of Schizophrenia

• The KCNH3 inhibitor ASP2905 shows potential in the treatment of attention deficit-hyperactivity disorder (Takahashi, 2018)

  • KCNH3 overexpression in mice is associated with cognitive deficits, and knockout mice exhibit enhanced performance in attention.
  • Increased efflux of Dopamine and Acetylcholine in the Medial Prefrontal Cortex.
  • Increased Alpha waves band power. (In frontal lobe)

• Wait a minute. Is this like a cleaner Guanfacine, if KCNH3 is concentrated in the dlPFC? I wonder what Arnsten would think of this.