10-Methoxyharmalan

2022-04-26: Drugs reference:

10-Methoxyharmalan (AKA 6-methoxyharmalan) #

Deivative of β-Carboline: ![100][beta-carboline.png] obtained by cyclodehydration of Melatonin.

• Similar to https://en.wikipedia.org/wiki/6-MeO-THH (Tetrahydroharman), which overall has a pretty low affinity for everything, but mainly 5-HT2C followed by 5-HT2A

• 10-Methoxyharmalan, a Potent Serotonin Antagonist Which Affects Conditioned Behavior (1961)

  • More potent than harmaline.
  • *The standard oxytocic response to 0.2 μg of serotonin was completely blocked by the addition of 0.5 μg of lysergic acid diethylamide, 2.0 pg of 10- methoxyharmalan (Fig. 2), 50 fig of harmaline (Fig. 3), or 50 μg of harmine to a 10-ml muscle bath 5 min before addition of the serotonin. At higher dose levels, the harmala alkaloids frequently caused contractions, and it was noted that if a contraction was elicited the subsequent serotonin antagonism was decreased. *
  • a potent antagonist of the myotropic action of serotonin

• All five β-carbolines are relatively potent inhibitors of PMAT (plasma membrane monoamine transporter). Possibly a tryptophan hydroxylasae inhibitor.

• Seems to be quite a potent MAO-A inhibitor in micromolar concentrations.

• Fourtillan made one of the discoveries of the century with Valentonine, the true sleep hormone.

  • Mode of action of mixed patches in neurological diseases due to insufficient secretion of Valentonine and 6-Methoxy-Harmalan by the pineal gland Application to the treatment of Parkinson’s disease
    • Inhibits D1 and α2 Adrenergic Receptor ligand binding. Valentonine does the opposite of 6-MH. I don’t see why this wouldn’t happen in the brain, but it is emphasize peripherally here that 1 antagonism increases Blood Pressure, heart rate, and contraction of muscle fibers, to facilitate ‘daytime mode’ of the Circadian Rhythm.
  • Welp https://www.lifesitenews.com/news/accomplished-pharma-prof-thrown-in-psych-hospital-after-questioning-official-covid-narrative/
    • the 11 compulsory vaccines for newborns in France contain 17 times the maximum dose of aluminum defined as toxic by the World Health Organization

• Anecdote:

  • Potent stimulant. Inhibits stress/anxiety reactions immediately.

Dosing #

• About twice as much as LSD for an equivalent opposite effect.