p75

2022-04-28: reference:

Low-affinity nerve growth factor receptor (LNGFR) (p75NTR) #

• All neurotrophins bind here with equal affinities (so BDNF/NGF/NT-3/4… and pro-BDNF.)
  • And also pro-BDNF/NGF: proNGF and proBDNF interact with p75NTR and cause p75NTR-mediated apoptosis without activating TrkA-mediated survival mechanisms.
    • Regulation of cell survival by secreted proneurotrophins
    • The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC
• in the absence of a co-expressed TrkA, the LNGFR may signal a cell to die via apoptosis…
• Surely receptors such as this play a role in BDNF induction of the catagen phase in Hair Loss?
• Activates JNK, causing apoptosis of developing neurons.
• But it can also be pro-survival: activating NF-κB. p75-Mediated NF-κB Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor