Tretinoin

2023-04-07:

MOA is by agonizing RAR (nuclear receptors) on Keratinocytes. RAR heteromerizes with RXR. The complex binds with RAREs (RA RA response elements) for all their downstream effects on transcription factors:
- EGF signaling for cell division-> epidermal hyperplasia.
- Competes for coactivator proteins of AP-1
- Cutting Edge: All-trans Retinoic Acid Down-Regulates TLR2 Expression and Function1
Topical tretinoin therapy and all-cause mortality
Look into Tazarotene. It’s stronger than .1% tretinoin, at least.

Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Up‐Regulating Follicular Sulfotransferase Enzymes Upregulating SULT enhances conversion of minoxidil to its active form, minoxidil sulfate.
Regarding the hayflick limit: the thing is, even though the division rate of Keratinocytes is being increased, epidermal stem cells are constantly making new ones.
https://www.reddit.com/r/tretinoin/comments/ia7v01/been_on_1_for_a_year_no_more_big_breakouts_but/
- Possible complications with fungal acne tdue to isopropyl myristate concent in tretinoin cream.
- Or just closed omedomes, which calls for some BHA.
NRF2 inhibitor.

= Meibomian gland damage
Blepharitis in the United States 2009: a survey-based perspective on prevalence and treatment
Wait 20-30 mins after washing to apply - and wait 20 minutes b efore skincare, moisturizer, etc.
- There are horror stories of dry eyes from it. People put vaseline around their eyes to block it out (thought vaseline itself could ry it out)
  - Or aquaphor, that stuff i used as chapstick I’m pretty sure
- (Sandwich method: light moisturizing both before and after.)
  - The initial moisture might give extra penetration, though.

Keep away from the corners of the nose, mouth, and the eyes of course.
Retinization: Dryness and peeling, and then the purge, with more acne etc. Lasts a few weeks or up to many months before progress ensues. Apparently this doesn’t have to happen. But it does 2-4 weeks after beginning.
- Due to opening of microcomedones.
I read it’s much better for consistent low dose than infrequent high dose. https://www.reddit.com/r/tretinoin/comments/12j166t/in_defense_of_rapid_retinization/ doing it nightly right off the bat might get retinization over with. Perhaps it lets the stratum corneum get thinned out ASAP.
A lot of people, for instance on reddit, combine it with Azelaic Acid after a certain point.
- I think you start with using it separately in the morning and then morning+night (so with tret) once you acclimate to the AZA - apply after for the retinols to absorb better.
  - Alternatively, I could use it on nights I don’t use tret. 15%+
0.025-0.1 have the same anti-aging benefits after 1 year mark?
Thickens the deeper layers over time, while compacting (not destroying or whatever) the stratum corneum.

Salicylic Acid could contribute to irritation?
Niacinamide probably mixes well. Some people say it’s comedogenic and it mya exacerbate but who knows

I’vew heard highstreetpharma as well which is a modafinil site I recognize.
Altreno is a new product. Not vegan I think. And it’s just paired with random hydrating stuff, I dunno.
Mixed reviews on what formulation…
- Gel: Usually easier to spread, and may be more moisturizing.
- Cream: Emolient (moisturizing) ones are the best kind.
  - Pretty clean formulation also. Mostly FA/FA alcohols.
  - Supposedly the isoproyl myristate can be irritating and lead to purging!
- Lotion like altreno might be the best of all types. Highstreetpharma.com: their crypto payment service is verboten in the US. Although I wonder if it has no effect on the actual shipping address
Skinorac.com: legit, but their only reliable payment method is gift cards (literallly do not redeem) Skincareex.net Alldaychemist.com Tarasc.com
Thebeautybliss.com: well-received but always out of stock
- Their cream is Tretiheal, which is available elsewhere.
- Amazon pay only Reliablerxpharmacy.com
Tretin = Bunk. But at least it’s soothing.
Tretiheal = probably weak too.
Mercari gel might be my only saving grace
https://www.buy-pharma.md/Tretinoin-p-173.html?

Goodrx somehow makes coupons. I have no idea how it workss

yana-notes