Thyroid Hormone Receptor

2022-10-01:

Thyroid Hormone Receptor #

• Nuclear receptor.
• The most transcriptionally active form of THR are the heterodimers with RXR.

Subtypes #

There’s a THRA and THRB gene. Thyroxine binds to α1 and β1-3.

• α1
  • widely expressed; high expression in cardiac and skeletal muscles, brown fat, and bone
• α2
  • widely expressed; high expression in skeletal muscles, brain, and kidney
• α3
  • widely expressed; high expression in skeletal muscle, brain, and kidney
• β1
  • widely expressed; predominately in brain, liver, and kidney
  • Sobetirome (GC-1) is a pharma agonist.
    • Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats
• β2: Primarily in the Retina, hypothalamus, anterior pituitary, and cochlea
• β3: