Suprachiasmatic Nucleus
2022-08-17: reference:
Suprachiasmatic Nucleus #
- Located in the Hypothalamus; pacemaker of the Circadian Rhythm.
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Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice
- Adenosine acts upon the circadian clockwork via A1/A2A signalling through the activation of the Ca2+ -ERK-AP-1 and CREB/CRTC1-CRE pathways to regulate Per1 and Per2.
- Interesting how A1 and A2A antagonism balances out Caffeine being a zeitgeber by differentially disinhibiting and inhibiting cAMP->CREB.
- Adenosine acts upon the circadian clockwork via A1/A2A signalling through the activation of the Ca2+ -ERK-AP-1 and CREB/CRTC1-CRE pathways to regulate Per1 and Per2.