Sphingomyelin

2022-06-30: reference:

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Consists of Phosphocholine/Ceramide/phosphoethanolamine head group.

• Role of sphingolipids in senescence: implication in aging and age-related diseases

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  • Senescent cells have increased β-Galactosidase activity, and Ceramide induces expression of the senescence histochemical marker, beta-galactosidase, in human fibroblasts. C6-ser directyl activates PP1 and PP2A, and induces p21 expression and association with CDK2.

Metabolism #

• Subcellular localization of enzymes:
• Niemann-Pick disease is a series of sphingolipidoses, inherited metabolic disorders, of which there are many, and prevalent in Jews. Sphingomyelin accumulates in Lysosomes. Type A is fatal in infancy, while B sees survival into adulthood and apparently has no neurologic manifestations. C1 is the most common form and leads to dementia.
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    • Please bear in mind most if not all of these steps are reversible by other enzymes.