Spermidine

2021-11-22 links: reference:

• https://raypeatforum.com/community/threads/the-travis-corner.21611/post-303590

Spermidine #

• Polyamine; Spermine precursor (spermine synthase).

• Increased longevity in yeast due to autophagy.

• Required for hypusination of elF5A, a transcription factor for TFEB.

• Loss of the autophagy-related proteins ATG5 and ATG7 in neurons provokes premature death and neurodegeneration in mice. (It crosses the BBB)

• [Spermidine, a polyamine site agonist, attenuates working memory deficits caused by blockade of hippocampal muscarinic receptors and mGluRs in rats]

• Acts on NMDAR, acutely enhancing cognitive performance

• Increased polyamine synthesis seen in several Cancers.

• Dietary spermidine improves cognitive function

  • 57% of control mice, 91% of 3mM SPD-fed mice, and 75% of 6mM completed the Morris water maze after 4 days.
  • No improvements in female mice, because they were better by default, even after the males supplemented. I’m noticing sex differences in some of these obscure supplements.
  • 30 mM for 30 days elicited maladaptive effects on muscle strength, attributed to excessive autophagy activation.
    • Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice

• Rich in aged cheese, mushrooms. Dietary consumption is like 5-25mg/day.