Sarcosine

2022-01-25 links: reference:

Sarcosine (N-methylglycine) #

• Glycine Transporter 1 inhibitor.
  • This potentiates AMPA, and NMDA, hence it’s sometimes used as an adjuvant in schizophrenia medication.
    • Adjunctive sarcosine plus benzoate improved cognitive function in chronic schizophrenia patients with constant clinical symptoms: A randomised, double-blind, placebo-controlled trial
  • This is also a D-Serine transporter.
• The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine
  • Functions as a NMDAR coagonist. A better one than glycine, too: less NMDAR desensitization occurred with sarcosine than with glycine as the co-agonist.
    • Btw there are multiple means of desensitization at NMDAR
• Stimulates macroautophagy over a background of enhanced mTOR signaling, likely by potentiating the stimulatory effect of AMPK on macroautophagy: Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans
• AMPA Receptor-mTOR Activation is Required for the Antidepressant-Like Effects of Sarcosine during the Forced Swim Test in Rats: Insertion of AMPA Receptor may Play a Role
  • Increase in AMPAR/NMDAR ratio? Simply due to insertion; like, does the same thing not happen with NMDAR bro?
• Sarcosine (glycine transporter inhibitor) attenuates behavioural and biochemical changes induced by ketamine, in the rat model of schizophrenia
  • ameliorated oxidative and nitrosative stress, mitochondrial dysfunction, and neuroinflammation
• Serum sarcosine is not a marker for prostate cancer

Dose #

It’s on Everychem @ $25/100g.

• Underrated asf? JC took it with Ginkgo and TAK and said it’s peak cognition.
  • Increases prefrontal dopamine somehow
  • He compares it to Cinnamaldehyde for some reason?
• Potent analgesic